85-6309-60　TLK1（Phospho Ser764） Rabbit Polyclonal Antibody 20ul　BT-AP05130

特徴

• 背景：Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Cell-cycle regulated| maximal activity in S-phase. Inactivated by phosphorylation at Ser-743| potentially by CHK1.|Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23| augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro| phosphorylates histone H3 at 'Ser-10'.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|Contains 1 protein kinase domain.|subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.|tissue specificity:Widely expressed. Present in fetal placenta| liver| kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.|

仕様

• サイズ：20ul
• 抗原：Synthesized peptide derived from human TLK1 (Phospho Ser764)
• 免疫動物：Rabbit
• 交差性：Human, Rat, Mouse
• 適用：WB, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：TLK1 ;Phospho Ser764
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