85-6280-01　HMP19 Polyclonal Antibody 50ul　BT-AP04150

特徴

• 背景：The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility. The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas. PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility. ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation.

仕様

• サイズ：50ul
• 抗原：The antiserum was produced against synthesized peptide derived from human NSG2. AA range:33-82
• 免疫動物：Rabbit
• 交差性：Human;Mouse
• 適用：IHC-p, WB, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：NSG2; Neuron-specific protein family member 2; Protein p19; Hmp19
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