85-6263-59　GluR-Delta2 Polyclonal Antibody 100ul　BT-AP03602

特徴

• 背景：The glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

仕様

• サイズ：100ul
• 抗原：The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
• 免疫動物：Rabbit
• 交差性：Human;Mouse;Rat
• 適用：WB, IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
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