85-6236-63　Dok-3 Polyclonal Antibody 20ul　BT-AP02699

特徴

• 背景：Dok-1, Dok-2 and Dok-3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.

仕様

• サイズ：20ul
• 抗原：The antiserum was produced against synthesized peptide derived from human DOK3. AA range:101-150
• 免疫動物：Rabbit
• 交差性：Human;Mouse
• 適用：WB, IHC-p, IF, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：DOK3; Docking protein 3; Downstream of tyrosine kinase 3
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