85-6191-21　Caspase-1 Polyclonal Antibody 50ul　BT-AP01191

特徴

• 背景：CASP1 encodes a protein (caspase 1) which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

仕様

• サイズ：50ul
• 抗原：The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
• 免疫動物：Rabbit
• 交差性：Human;Rat
• 適用：IF, WB, IHC-p, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
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