85-6168-23　AR Polyclonal Antibody 20ul　BT-AP00399

特徴

• 背景：The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain| DNA-binding domain| and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand| the receptor dissociates from accessory proteins| translocates into the nucleus| dimerizes| and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

仕様

• サイズ：20ul
• 抗原：The antiserum was produced against synthesized peptide derived from human Androgen Receptor. AA range:331-380
• 免疫動物：Rabbit
• 交差性：Human, Mouse, Rat
• 適用：WB, ELISA
• クラス：IgG
• クロナリティ：Polyclonal
• 濃度：1 mg/ml
• 別名：Androgen receptor; AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
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