85-6156-46　Tumor Necrosis Factor Receptor Superfamily member 10B, Active, Recombinant, Mouse, hFc-Tag, aa53-177 (Tnfrsf10b) 10ug　587056

特徴

• Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
• Partial recombinant protein corresponding to aa53-177 from mouse Tumor necrosis factor receptor superfamily member 10B, fused to hFc-Tag at C-terminal, expressed in Mammalian cell.
• Molecular Weight:~40.9kD
• Biological Activity:The ED50 as determined by its ability to inhibit TRAIL-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TRAIL is less than 1ug/ml.
• Amino Acid Sequence:NPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWAS
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.