85-6127-73　Non-receptor Tyrosine-protein Kinase TYK2, Recombinant, Human, aa556-871, His-Tag, Myc-Tag 20ug　585530

特徴

• The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the aa556-871 of the human TYK2 protein and the N-terminal 10xHis-Tag and C-terminal Myc-Tag gene. The product was purified and isolated to get the recombinant human TYK2 protein with N-terminal 10xHis-Tag and C-terminal Myc-Tag. This recombinant TYK2 protein's purity reaches up to 85%.
• TYK2 is a gene encoding an enzyme named non-receptor tyrosine-protein kinase TYK2 (abbreviated TYK2) and belongs to protein kinase superfamily or tyr protein kinase family. This protein is observed in all cell lines analyzed and expressed in a variety of lymphoid and non-lymphoid cell lines. This enzyme can transfer the phosphate group from ATP to a tyrosine residue of a protein (phosphorylation). It plays a key role in many cellular functions by switching on or switching off other enzymes in a cell as a regulator. Disease associated with TYK2 includes immunodeficiency 35. This protein is probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling.
• Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
• Source:Recombinant protein corresponding to aa556-871 from human Non-receptor tyrosine-protein kinase TYK2, fused to 10X His-Tag at N-terminal and Myc-Tag at C-terminal, expressed in E.coli.
• Molecular Weight:~42.6kD
• Amino Acid Sequence:GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQP
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.