Zika virus (ZIKV) is a member of the Flavivirus genus of the family Flaviviridae that also includes global human pathogenic viruses Dengue virus (DENV), Yellow Fever virus, West Nile virus and Japanese encephalitis virus.
Zika infection is an emerging disease caused by Zika virus, which is spread through the bite of infected Aedes mosquitoes. The Zika virus was first isolated in Central Africa but has since spread to South Asia and South America. The Zika virus can also be transmitted to individuals through sexual contact, blood product transfusion and organ transplant (WHO, 2018). Zika virus can also be transmitted to the foetus during pregnancy causing microcephaly (CDC).
Healthy individuals infected with Zika virus may remain asymptomatic or can experience mild fever, rash, myalgia, arthralgia and headaches. In addition, Zika virus infection in adults has been associated with neuropathy, myelitis and the neurological condition Guillain-Barre syndrome.
Due to similar symptoms, Zika virus infection can be misdiagnosed as a Dengue virus infection and vice-versa. Currently, there are no vaccines available for the prevention of Zika virus. Therefore, accurate diagnosis of ZIKV is essential for patient management especially in regions where DENV and ZIKV co-circulate. However, ZIKV and DENV show structural and genetic similarities, and serological testing for the viruses can be complicated by problems of cross-reactivity.
During ZIKV infection, neutralizing antibodies are produced that predominantly target ZIKV envelope proteins Immunoglobulin-like domain III (DIII). Consequently, neutralizing antibodies targeting ZIKV DIII envelope proteins have attracted significant interest due to their therapeutic and prophylactic potential (Yang, C. et al)
Applications:Suitable for use in ELISA, Western Blot and Lateral Flow. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Source Antigen：Recombinant, E. coli
Grade：Highly Purified
Purity：≥95% (SDS-PAGE)
Form：Supplied as a liquid in 20mM Carbonate buffer, pH 10.0.
