Canine parvovirus (also called CPV or parvo) is a contagious virus mainly affecting canines, but which can also infect other mammals including foxes, wolves, felines, and skunks (Holmes et al., 2013). There are two types of canine parvovirus called canine minute virus (CPV1) and CPV2. CPV2 causes the most serious disease and there are variants of CPV2 called CPV-2a and CPV-2b (Shackelton et al., 2005).
CPV2 is a non-enveloped single-stranded DNA virus in the Parvoviridae family. The virus is very similar to feline panleukopenia (also a parvovirus) and they are 98% identical at the amino-acid level, differing only in two amino-acids in the viral capsid protein, VP2 (Carter & Wise, 2004). CPV2 is highly contagious and is spread from canine to canine by direct or indirect contact with their feces or virus-contaminated fomites. Virus is shed in the feces of infected canines within 4–5 days of exposure, throughout illness, and for approximately ten days after clinical recovery. Clinical signs of parvovirus include lethargy, loss of appetite, abdominal pain and bloating, fever or low body temperature (hypothermia), vomiting, and severe, often bloody, diarrhea. Persistent vomiting and diarrhea can cause rapid dehydration, and damage to the intestines and immune system, resulting in septic shock. Canines infected with parvovirus usually die from the dehydration or from secondary infection, rather than the virus itself. There is no specific antiviral drug that will kill the virus in infected canines, but vaccines are available. However, mortality can be as high as 91% in unvaccinated populations.
Source: Canine Parvovirus, strain Cornell-780916-115 from CRFK cells.
Applications: Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Inactivation:UV and detergent inactivated.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
