85-6085-10　［受注停止］ULBP-3, Recombinant, Human, aa30-217, hIgG-His-Tag 20ug　497089

特徴

• ULBP-3, also known as NKG2D ligand 3, is ligands for natural-killer group 2, member D (NKG2D) receptor. It is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3differs significantly from those of conventional MHC class I molecules. It does not contain the alpha3 domain and the transmembrane segment. ULBP3 is thus composed of only the alpha1alpha2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. In the normal hair follicle, ULBP3 is turned off. However, different studies reported its high level in alopecia areata (AA). It is also expressed on some tumor cells and have been implicated in tumor surveillance.
• Recombinant protein corresponding to aa30-217 from human ULBP-3, fused to hIgG-His-Tag at C-terminal, expressed in Baculovirus.
• Molecular Weight:~49.3kD
• Amino Acid Sequence:＜ADP＞DAHSLWY NFTIIHLPRH GQQWCEVQSQ VDQKNFLSYD CGSDKVLSMG HLEEQLYATD AWGKQLEMLR EVGQRLRLEL ADTELEDFTP SGPLTLQVRM SCECEADGYI RGSWQFSFDG RKFLLFDSNN RKWTVVHAGA RRMKEKWEKD SGLTTFFKMV SMRDCKSWLR DFLMHRKKRL EPTAPPTMAP G＜LEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVDKSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.