85-6084-71　Resistin, Recombinant, Human, aa19-108, His-Tag 20ug　497070

特徴

• Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid specific secreted cysteine-rich protein (XCP1) is a cysteine-rich peptide hormone derived from adipose tissue itparticipates in the inflammatory response. It plays some role in inflammation, glucose metabolism, and angiogenesis. In primates, pigs, and canines, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose tissue. Although the function of resistin is unclear, it would seem to block insulinstimulated uptake of glucose by adipocytes and promote glucose release by hepatocytes. As such, it has been proposed to participate in diet‑induced insulin-sensitivity. It has been also shown to cause high levels of lowdensity lipoprotein (LDL), increasing the risk of heart disease. It has been shown to increase transcriptionalevents, leading to an increased expression of several pro-inflammatory cytokines including IL-1, IL-6, IL-12 and TNF-alpha in an NF-kappa B-mediated fashion. Also, resistin could act as a key node in inflammatory diseases with or without associated insulin resistance.
• Recombinant protein corresponding to aa19-108 from human Resistin, fused to His-Tag at C-terminal, expressed in HEK293 cells.
• Molecular Weight:~10.3kD
• Amino Acid Sequence:KTLCSMEEAI NERIQEVAGS LIFRAISSIG LECQSVTSRG DLATCPRGFA VTGCTCGSAC GSWDVRAETT CHCQCAGMDW TGARCCRVQP ＜HHHHHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.