85-6084-63　Noggin, Recombinant, Human, aa28-232, His-Tag 20ug　497066

特徴

• NOG, also known as noggin, is a secreted protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP) -signaling pathway. It binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. This protein is an inhibitor of several bone morphogenetic proteins and cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions. It also plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signalinginhibitors.
• Recombinant protein corresponding to aa28-232 from human Noggin, fused to His-Tag at C-terminal, expressed in HEK293 cells.
• Molecular Weight:~23.8kD
• Amino Acid Sequence:QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC＜HHHHH H＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.