85-6084-33　［受注停止］IL-17E, Recombinant, Human, aa33-177, His-Tag 20ug　497043

特徴

• IL-25, also known as IL-17E, belongs to the IL-17 cytokine family. It support the Th2 immune response, and has been shown to induce the production of IL-4, IL-5 and IL-13. This is in contrast to other IL-17 family memberswhich promote Th1- and Th17-biased inflammation. Because IL-25 promotes the development of a Th2 immune response, it acts to protect against several bowel infections caused by helminths. It is also referred to as the regulator of IL-9 production. IL-25 has been shown to increase the production of IL-9 in Th9 cells. Another function of this protein is the activation of natural lymphoid cells. IL-25 and IL-33 are the most potent activators of ILC2. IL-25 has potent antitumor activity in vivo in several human cancers including melanoma, breast, lung, colon, and pancreatic cancers, suggesting the potential clinical use of IL-17E as an anticancer agent.
• Recombinant protein corresponding to aa33-177 from human IL-17E/IL-25, fused to His-Tag at C-terminal, expressed in HEK293 cells.
• Molecular Weight:~17.8kD
• Biological Activity:Measured by its binding ability in a functional ELISA with Human IL-17 RB.
• Amino Acid Sequence:＜DGS＞YSHWPSC CPSKGQDTSE ELLRWSTVPV PPLEPARPNR HPESCRASED GPLNSRAISP WRYELDRDLN RLPQDLYHAR CLCPHCVSLQ TGSHMDPRGN SELLYHNQTV FYRRPCHGEK GTHKGYCLER RLYRVSLACV CVRPRVMG＜HH HHHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.