85-6083-89　CD200, Recombinant, Human, aa31-232, His-Tag 10ug　497022

特徴

• CD200, also known as OX-2 membrane glycoprotein isoform a, belongs to the immunoglobulin superfamily. This protein imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. D200 and CD200R associate via their respective N-terminal Ig-like domains. CD200-CD200R signaling have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
• Recombinant protein corresponding to aa31-232 from human CD200, fused to His-Tag at C-terminal, expressed in Baculovirus.
• Molecular Weight:~23.5kD
• Biological Activity:Measured by its binding ability in a functional ELISA with Human CD200R1
• Amino Acid Sequence:＜ADP＞QVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKG＜HHHHH H＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.