85-6052-39　UNC5H2/UNC5B, Recombinant, Rat, aa27-373, hIgG-His-Tag 100ug　552355

特徴

• UNC5B/UNC5B, also known as Netrin receptor UNC5B, is one of four related receptors that comprise the UNC5 family and serve as receptors for the axon guidance molecule Netrin-1. Outside of the nervous system, UNC5B facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration, as well as Netrin-1-mediated promotion of osteoclast differentiation. Also this protein activates DAPK1 which mediates apoptosis. It is believed to play a role in tumorgenesis. Additionally, It is thought to play a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
• Source:Recombinant protein corresponding to aa27-373 from rat UNC5H2/UNC5B protein, fused to hIgG-His-Tag at C-terminal, expressed in HEK293.
• AA Sequence:＜DGSM＞GIDSGG QALPDSFPSA PAEQLPHFLL EPEDAYIVKN KPVELHCRAF PATQIYFKCN GEWVSQKGHV TQESLDEATGLRIREVQIEV SRQQVEELFG LEDYWCQCVA WSSSGTTKSR RAYIRIAYLR KNFDQEPLAK EVPLDHEVLL QCRPPEGVPVAEVEWLKNED VIDPAQDTNF LLTIDHNLII RQARLSDTAN YTCVAKNIVA KRRSTTATVI VYVNGGWSSW AEWSPCSNRCGRGWQKRTRT CTNPAPLNGG AFCEGQACQK TACTTVCPVD GAWTEWSKWS ACSTECAHWR SRECMAPPPQNGGRDCSGTL LDSKNCTDGL CVLNQRTLND PKSRPLEPSG D＜VEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMISRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIEKTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVDKSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.