85-6051-67　SPARC, Recombinant, Mouse, aa18-302, His-Tag 50ug　552296

特徴

• SPARC, also known as osteonectin and BM40, is a secreted matricellular glycoprotein that belongs to a group of functionally related glycoproteins that includes tenascins C and X, thrombospondins 1 and 2, and osteopontin. It is a major bone-related protein that is also present in nonmineralized tissues and in platelets and is matricellular molecule regulating interactions between cells and their surrounding extracellular matrix (ECM). This protein is produced by fibroblasts, capillary endothelial cells, platelets and macrophages, especially in areas of tissuemorphogenesis and remodeling. It shows context-specific effects, but generally inhibits adhesion, spreading and proliferation, and promotes collagen matrix formation. It is abundantly expressed in bone, where it promotes osteoblast differentiation and inhibits adipogenesis.
• Source:Recombinant protein corresponding to aa18-302 from mouse SPARC, fused to His-Tag at C-terminal, expressed in baculovirus.
• AA Sequence:APQQTEVAEE IVEEETVVEE TGVPVGANPV QVEMGEFEDG AEETVEEVVA DNPCQNHHCK HGKVCELDES NTPMCVCQDPTSCPAPIGEF EKVCSNDNKT FDSSCHFFAT KCTLEGTKKG HKLHLDYIGP CKYIAPCLDS ELTEFPLRMR DWLKNVLVTLYERDEGNNLL TEKQKLRVKK IHENEKRLEA GDHPVELLAR DFEKNYNMYI FPVHWQFGQL DQHPIDGYLS HTELAPLRAPLIPMEHCTTR FFETCDLDND KYIALEEWAG CFGIKEQDIN KDLVI＜HHHHH H＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.