85-6049-21　LRIG1, Recombinant, Mouse, aa35-796, His-Tag (Leucine Rich Repeats And Immunoglobulin Like Domains Protein 1) 50ug　552063

特徴

• LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGFfamily of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse.
• Source:Recombinant protein corresponding to aa35-796 from mouse LRIG1, fused to His-Tag at C-terminal, expressed in baculovirus.
• AA Sequence:AQAGPRAPCA AACTCAGDSL DCSGRGLATL PRDLPSWTRS LNLSYNRLSE IDSAAFEDLT NLQEVYLNSN ELTAIPSLGAASIGVVSLFL QHNKILSVDG SQLKSYLSLE VLDLSSNNIT EIRSSCFPNG LRIRELNLAS NRISILESGA FDGLSRSLLTLRLSKNRITQ LPVKAFKLPR LTQLDLNRNR IRLIEGLTFQ GLDSLEVLRL QRNNISRLTD GAFWGLSKMH VLHLEYNSLVEVNSGSLYGL TALHQLHLSN NSISRIQRDG WSFCQKLHEL ILSFNNLTRL DEESLAELSS LSILRLSHNA ISHIAEGAFKGLKSLRVLDL DHNEISGTIE DTSGAFTGLD NLSKLTLFGN KIKSVAKRAF SGLESLEHLN LGENAIRSVQ FDAFAKMKNLKELYISSESF LCDCQLKWLP PWLMGRMLQA FVTATCAHPE SLKGQSIFSV LPDSFVCDDF PKPQIITQPE TTMAVVGKDIRFTCSAASSS SSPMTFAWKK DNEVLANADM ENFAHVRAQD GEVMEYTTIL HLRHVTFGHE GRYQCIITNH FGSTYSHKARLTVNVLPSFT KIPHDIAIRT GTTARLECAA TGHPNPQIAW QKDGGTDFPA ARERRMHVMP DDDVFFITDV KIDDMGVYSCTAQNSAGSVS ANATLTVLET PSLAVPLEDR VVTVGETVAF QCKATGSPTP RITWLKGGRP LSLTERHHFT PGNQLLVVQNVMIDDAGRYT CEMSNPLGTE RAHSQLSILP TPGCRKDGTT VG＜VEHHHHHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.