85-6048-10　GDNF, Recombinant, Human, aa109-211, His-Tag 50ug　551970

特徴

• GDNF, also known as Glial cell-derived neurotrophic factor, is a member of the GDNF family of ligands (GFL). This Protein has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. It promotes the survival of many types of neurons and signals through GFRa receptors, particularly GFRa1. These neuronal populations die in the course of Parkinson's disease and amyotrophic lateral sclerosis (ALS). GDNF also regulates kidney development and spermatogenesis, and has a powerful and rapid negative (ameliorating) effect on alcohol consumption.
• Source:Recombinant protein corresponding to aa109-211 from human GDNF, fused to His-Tag at C-terminal, expressed in baculovirus.
• AA Sequence:＜ADPM＞RGQRGK NRGCVLTAIH LNVTDLGLGY ETKEELIFRY CSGSCDAAET TYDKILKNLS RNRRLVSDKV GQACCRPIAFDDDLSFLDDN LVYHILRKHS AKRCGCI＜HHH HHH＞
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.