ACE2, also known as angiotensin-converting enzyme 2, is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE. ACE2 cleaves angiotensin 1 to angiotensin 1-9 and angiotensin 2 to angiotensin 1-7 as a carboxypeptidase. It may be an important regulator of heart function and have a protective role in acute lung injury.
Recombinant protein corresponding to Gln18-Ser740 from human ACE2, fused to His-Tag and Avi-Tag at C-terminal, expressed in HEK293 cells.
Biological Activity:Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human ACE2-His at 2ug/mL (100ul/well) can bind Recombinant 2019-nCoV Spike S1 with a linear range of 1.5-104.5ng/ml.
Storage and Stability:Lyophilized and reconstituted products may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：100ug
Source Antigen：Recombinant, HEK293 cells
Grade：Highly Purified
Purity：≥95% (SDS-PAGE). Endotoxin: <1EU/ug (LAL)
Form：Supplied as a lyophilized powder from a 0.22um filtered solution of PBS, pH 7.4. Reconstitute to 0.1-0.5mg/ml in sterile ddH2O.
