85-6037-22　FGF-23, Recombinant, Human, aa25-251, His-Tag 50ug　532303

特徴

• FGF-23, also known as fibroblast growth factor 23, is a member of the FGF family which is responsible for phosphate and vitamin D metabolism. The main function of this protein seems to be regulation of phosphate concentration in plasma. It is secreted by osteocytes in response to elevated calcitriol and acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF-23 interaction with renal proximal tubular epithelium decreases the reabsorption and increases excretion of phosphate. This protein may also suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption. Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The N-terminal sequence analysis is showing that a C-terminal fragment is detected.
• Source:Recombinant protein corresponding to aa25-251 from human FGF-23, fused to His-Tag at C-terminal expressed in Baculovirus.
• Molecular Weight:~26.4kD (236aa)
• Endotoxin:~1EU/1ug (LAL)
• AA Sequence:ADPYPNASPL LGSSWGGLIH LYTATARNSY HLQIHKNGHV DGAPHQTIYS ALMIRSEDAG FVVITGVMSR RYLCMDFRGN IFGSHYFDPE NCRFQHQTLE NGYDVYHSPQ YHFLVSLGRA KRAFLPGMNP PPYSQFLSRR NEIPLIHFNT PIPRRHTRSA EDDSERDPLN VLKPRARMTP APASCSQELP SAEDNSPMAS DPLGVVRGGR VNTHAGGTGP EGCRPFAKFI HHHHHH
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.