85-6037-16　FGF R1 alpha, Recombinant, Human, aa22-374, His-Tag 50ug　532300

特徴

• FGF R1 alpha, also known as fibroblast growth factor receptor 1 isoform 2, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is related fibroblast growth factor (FGF) receptors that are involved in physiological and pathological processes such as cell division, regulation of cell growth and maturation, formation of blood vessels and embryonic developments. The biological activities of the FGFs are meditated by a family of type 1 transmembrane tyrosine kinases which undergo dimerization and auto-phosphorylation after ligand binding. Also, this protein is thought to play an important role in the development of the nervous system. It may also help regulate the growth of long bones, such as the large bones in the arms and legs. Defects in FGF R1 alpha are associated with various congenital malformations of the musculoskeletal system: these include the Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome.
• Source:Recombinant protein corresponding to aa22-374 from human FGF R1 alpha, fused to His-Tag at C-terminal expressed in Baculovirus.
• Molecular Weight:~40.1kD (361aa)
• Endotoxin:~1EU/1ug (LAL)
• AA Sequence:RPSPTLPEQA QPWGAPVEVE SFLVHPGDLL QLRCRLRDDV QSINWLRDGV QLAESNRTRI TGEEVEVQDS VPADSGLYAC VTSSPSGSDT TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNPVAP YWTSPEKMEK KLHAVPAAKT VKFKCPSSGT PNPTLRWLKN GKEFKPDHRI GGYKVRYATW SIIMDSVVPS DKGNYTCIVE NEYGSINHTY QLDVVERSPH RPILQAGLPA NKTVALGSNV EFMCKVYSDP QPHIQWLKHI EVNGSKIGPD NLPYVQILKT AGVNTTDKEM EVLHLRNVSF EDAGEYTCLA GNSIGLSHHS AWLTVLEALE ERPAVMTSPL YLELEHHHHH H
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.