Human Respiratory Syncytial Virus (RSV) is a single-stranded RNA virus, which was first isolated in 1956 from a laboratory chimpanzee with a respiratory illness and was later discovered to be of human origin. RSV consists of two antigenic subtypes, A and B. Subtype B tend to produce asymptomatic infections, whilst the more severe illnesses which predominate during outbreaks are associated with subtype A strains. RSV is the leading cause of lower respiratory tract infections, including pneumonia and bronchiolitis in young infants. Approximately two thirds of infants are infected with RSV within their first year and 90% have been infected by the age of 2. It may cause mortality or morbidity in the elderly as well as immunodeficient individuals. It is the most common pathogen leading to hospitalization in young children up to the age of 5. The virion of Respiratory Syncytial Virus (RSV) contains three surface glycoproteins, the attachment protein G, fusion protein F, and the small hydrophobic SH protein.
Glycoprotein G is a type II transmembrane glycoprotein and is the major RSV attachment protein. It contains a single hydrophobic region which serves as a signal peptide and also as a membrane anchor. The structure and function of RSV glycoproteins has been reviewed by McClellan et al (2013).
Recombinant protein corresponding to aa67-298 of Respiratory Syncytial virus Glycoprotein G, Long strain, fused to a C-terminal mouse IgG2a Fc-tag with a 15aa glycine-serine linker, expressed in HEK293 cells.
Molecular Weight:~25kD
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
