85-6016-87 Von Hippel-Lindau Disease Tumor Suppressor, Recombinant, Human, aa1-213, His-Tag (VHL) 20ug 518156
特徴
- Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
- Recombinant full length protein corresponding to aa1-213 of human Von Hippel-Lindau Disease Tumor Suppressor, fused to 6X His-Tag at N-terminal, expressed in E. coli (P40337).
- Molecular Weight:~28.2kD
- Amino Acid Sequence:MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
- Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
- Size：20ug
- Source Antigen：Recombinant, E. coli
- Grade：Purified
- Purity：≥85% (SDS-PAGE)
- Form：Supplied as a liquid in Tris-HCl, pH 8.0, 1mM EDTA, 50% glycerol.
- Molecular Weight Non Ab：28.2
- Swiss Prot Number：P40337
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