85-6010-08 Alpha-Conotoxin VxXXC, Recombinant, Conus Vexillum, aa1-47, His-Sumo-Tag, Myc-Tag 200ug 517798
特徴
- Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA.
- Source:Recombinant full length protein corresponding to aa1-47 of Conus Vexillum Alpha-Conotoxin VxXXC, fused to 10xHis-Sumo-Tag at N-terminal and Myc-Tag at C-terminal, expressed in E. coli.
- Molecular Weight:~25.3kD
- AA Sequence:DLRQCTRNAPGSTWGRCCLNPMCGNFCCPRSGCTCAYNWRRGIYCSC
- Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
- Size：200ug
- Source Antigen：Recombinant, E. coli
- Grade：Purified
- Purity：≥85% (SDS-PAGE)
- Form：Supplied as a liquid in Tris-HCl, pH 8.0, 1mM EDTA, 50% glycerol.
- Molecular Weight Non Ab：25.3
- Swiss Prot Number：P0C1W7
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