Chikungunya Virus E2 Envelope protein is a unique product that has been developed in response to the need for high purity, properly assembled and glycosylated Chikungunya virus antigens for use in the development of Chikungunya virus diagnostics and in vaccine development and R&D (including use as an immunogen).
It has been reported that E2 protein may offer higher sensitivity in serological assays when compared to E1 protein (Cho et al, 2008).
Chikungunya virus is a member of the genus Alphavirus in the family Togaviridae. Chikungunya fever is a mosquito-borne disease first identified in Tanzania in 1953. Since 2004 there have been extensive outbreaks in Africa and Asia, and in 2013 the first cases were identified in the Caribbean, and by September 2014 more than 650,000 cases had been reported in the Americas. Chikungunya fever usually starts 2–4 days after chikungunya virus infection, with clinical symptoms including high fever, rash, headache, vomiting, myalgia, and severe joint pain
Because the virus is transmitted by the same mosquitos that transmit Dengue Virus and Zika Virus, and the clinical symptoms of infection with the viruses are also similar, it is important to be able to distinguish diagnostically between the different infections. Because the use of aspirin and other NSAIDs can increase the risk of hemorrhage in Dengue fever, patients should be treated as having Dengue fever until a diagnosis of Dengue fever has been excluded.
Source:Recombinant protein corresponding to aa326-693 of Chikungunya Virus E2 Envelope Protein, fused to a glycine-serine linker, and mouse IgG2a Fc-Tag at the C-terminal, expressed in HEK293 cells.
Strain:Senegal 37997
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Source Antigen：Recombinant, HEK293 cells
Grade：Highly Purified
Purity：~95% (Highly Purified)
Form：Supplied as a liquid in 50mM HEPES, pH 7.0, Triton X-100, 300mM sodium chloride.
