85-5998-89　Transferrin Receptor Protein 1 Isoform 1, Recombinant, Human, aa101-760, His-Tag (TFRC, CD71, IMD46, p90, T9, TFR, TFR1, TR, TRFR) 20ug　506199

特徴

• TFRC, also known as transferrin receptor protein 1, is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. It acts as cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. This protein is necessary for development of erythrocytes and the nervous system. And it is positively regulates T and B cell proliferation through iron uptake.
• Description:Recombinant protein corresponding to aa101-760 of human Transferrin Receptor Protein 1 Isoform 1, fused to His-tag at C-terminus, expressed in Baculovirus
• Molecular Weight:~74.9kD (669aa), ~70-100kD (SDS-PAGE under reducing conditions)
• Endotoxin:<1EU/1ug (LAL)
• AA Sequence:ADPLAGTESP VREEPGEDFP AARRLYWDDL KRKLSEKLDS TDFTGTIKLL NENSYVPREA GSQKDENLAL YVENQFREFK LSKVWRDQHF VKIQVKDSAQ NSVIIVDKNG RLVYLVENPG GYVAYSKAAT VTGKLVHANF GTKKDFEDLY TPVNGSIVIV RAGKITFAEK VANAESLNAI GVLIYMDQTK FPIVNAELSF FGHAHLGTGD PYTPGFPSFN HTQFPPSRSS GLPNIPVQTI SRAAAEKLFG NMEGDCPSDW KTDSTCRMVT SESKNVKLTV SNVLKEIKIL NIFGVIKGFV EPDHYVVVGA QRDAWGPGAA KSGVGTALLL KLAQMFSDMV LKDGFQPSRS IIFASWSAGD FGSVGATEWL EGYLSSLHLK AFTYINLDKA VLGTSNFKVS ASPLLYTLIE KTMQNVKHPV TGQFLYQDSN WASKVEKLTL DNAAFPFLAY SGIPAVSFCF CEDTDYPYLG TTMDTYKELI ERIPELNKVA RAAAEVAGQF VIKLTHDVEL NLDYERYNSQ LLSFVRDLNQ YRADIKEMGL SLQWLYSARG DFFRATSRLT TDFGNAEKTD RFVMKKLNDR VMRVEYHFLS PYVSPKESPF RHVFWGSGSH TLPALLENLK LRKQNNGAFN ETLFRNQLAL ATWTIQGAAN ALSGDVWDID NEFHHHHHH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.