85-5998-48　Haptoglobin Isoform 2, Recombinant, Human, aa19-347, His-Tag (HP, BP, HP2ALPHA2, HPA1S) 250ug　506176

特徴

• HP, also known as haptoglobin isoform 2, is consists of two alpha and two beta chains, connected by disulfide bridges in its simplest form. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. In blood plasma, this protein binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). It functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. For this reason, it is often referred to as the suicide protein.
• Description:Recombinant protein corresponding to aa19-347 of human HP, fused to His-tag at C-terminus, expressed in Baculovirus.
• Molecular Weight:~37.7kD (338aa), ~40-57kD (SDS-PAGE under reducing conditions)
• Endotoxin:<0.1EU/1ug (LAL)
• AA Sequence:ADLVDSGNDV TDIADDGCPK PPEIAHGYVE HSVRYQCKNY YKLRTEGDGV YTLNNEKQWI NKAVGDKLPE CEAVCGKPKN PANPVQRILG GHLDAKGSFP WQAKMVSHHN LTTGATLINE QWLLTTAKNL FLNHSENATA KDIAPTLTLY VGKKQLVEIE KVVLHPNYSQ VDIGLIKLKQ KVSVNERVMP ICLPSKDYAE VGRVGYVSGW GRNANFKFTD HLKYVMLPVA DQDQCIRHYE GSTVPEKKTP KSPVGVQPIL NEHTFCAGMS KYQEDTCYGD AGSAFAVHDL EEDTWYATGI LSFDKSCAVA EYGVYVKVTS IQDWVQKTIA ENHHHHHH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.