85-5998-28　CD200R1, Recombinant, Human, aa24-243, hIgG-His-Tag (Cell Surface Glycoprotein CD200 Receptor 1 Isoform d) 100ug　506165

特徴

• CD200R1, also known as cell surface glycoprotein CD200 receptor 1 isoform d, is a transmembrane protein in the immunoglobulin superfamily. This glycoprotein contains on C2 type Ig-like domain and V type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. Also, it is expressed on myeloid cells and CD4+ T cells. For function, this receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid down regulatory signal. Activation of CD200R1 regulates the expression of inflammatory molecules such as tumor necrosis factor (TNF-alpha), interferon and inducible nitric oxide synthase (iNOS).
• Description:Recombinant protein corresponding to aa24-243 of human CD200R1, fused to hIgG-His-tag at C-terminus, expressed in Baculovirus.
• Molecular Weight:~51.9kD (462aa) 50-70kD (SDS-PAGE under reducing conditions)
• Endotoxin:<1EU/1ug (LAL)
• AA Sequence:ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.