85-5998-19　［取扱停止］Angiogenin, Recombinant, Human, aa25-147, His-Tag (ANG) 10ug　506161

特徴

• ANG, also known as angiogenin, is a potent stimulator of new blood vessels through the process of angiogenesis. It is a key protein implicated in angiogenesis in normal and tumor growth. This protein interacts with endothelial and smooth muscle cells resulting in cell migration, invasion, proliferation and formation of tubular structures. It binds to actin of both smooth muscle and endothelial cells to form complexes that activate proteolytic cascades which upregulate the production of proteases and plasmin that degrade the laminin and fibronectin layers of the basement membrane. Also, it exhibits ribonucleolytic activity that is distinctly different than that of pancreatic RNase A. This ribonucleolytic activity of ANG toward most RNase A substrates is much lower than that of RNase A.
• Description:Recombinant protein corresponding to aa25-147 of human ANG, fused to His-tag at C-terminus, expressed in Baculovirus
• Molecular Weight:~15.2kD (132aa), ~13.5-18kD (SDS-PAGE under reducing conditions)
• Endotoxin:<1EU/1ug (LAL)
• AA Sequence:ADPQDNSRYT HFLTQHYDAK PQGRDDRYCE SIMRRRGLTS PCKDINTFIH GNKRSIKAIC ENKNGNPHRE NLRISKSSFQ VTTCKLHGGS PWPPCQYRAT AGFRNVVVAC ENGLPVHLDQ SIFRRPHHHH HH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.