85-5991-99　Transferrin Receptor, Soluble, Recombinant 100ug　474332

特徴

• The transferrin receptor (TfR) is the gateway for transferrin-bound-iron entering all body cells. TfR is abundant on the surface of many newly formed cells, but the erythroid narrow cells account for 70 to 80% of the total body TfR content. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein; it is an 85kD glycoprotein forming in serum a 320kD complex with diferric transferrin. The serum sTfR concentration reflects the total body mass of cellular transferrin receptor. Anemias associated with enhanced erythropoiesis and iron deficiency result in an elevation in the sTfR values. The normal sTfR concentrations are about 0.8-2.3ug/ml for adults, the iron deficiency may increase the values up to 20 fold.
• Elevation of the soluble transferrin receptor may be also caused by hemolytic anaemia, polycythemia and thalassemia while aplastic anemia and chronic renal failure may result in decrease. The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anemia and the anemia of chronic disease.
• Recombinant protein corresponding to Transferrin Receptor, Soluble, expressed in a HEK-293 Cell Line. Does not contain any tags.
• Applications:Suitable for use in ELISA and as an Immunogen for antibody production. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Molecular Weight:~73.8kD
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.