IL21, also known as interleukin-21 isoform 1, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of hematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cells, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate Janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells.
Recombinant protein corresponding to aa30-162 from human IL21, fused to His-Tag at C-terminal, expressed in Insect Cell.
Molecular Weight:~16.9kD (145aa)~18-28kD (SDS-PAGE under reducing conditions)
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：10ug
Source Antigen：Recombinant, Insect Cell
Grade：Purified
Purity：~85% (SDS-PAGE)
Form：Supplied as a liquid in PBS, pH 7.4, 20% glycerol.
