85-5907-59　Telotristat Ethyl 10mg　CAS No:1033805-22-9　466930

特徴

• Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Telotristat ethyl, also known as LX 1032 or LX 1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor. Telotristat etiprate has activity in controlling diarrhea associated with carcinoid syndrome. LX1606 acts by inhibiting the enzyme tryptophan hydoxylase (TPH) and reduces serotonin production both inside and outside the GI tract without affecting brain serotonin levels. TPH is the rate-limiting enzyme involved in serotonin biosynthesis and is present in metastatic carcinoid tumor cells.
• Synonyms:(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic Acid Ethyl Ester; LX 1032; LX 1606
• Molecular Formula:C₂₇H₂₆ClF₃N₆O₃
• Molecular Weight:574.98
• Appearance:White to off-white solid
• Purity:≥97%
• Melting Point:80-82°C (lit)
• Solubility:DMSO
• Method for Determining Identity:Proton NMR and Mass Spectroscopic Analysis
• Storage and Stability:Store at -20°C. Stable for 6 months after receipt.