TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3uM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Molecular Formula:C₁₁₁H₁₈₈N₄₂O₂₄S₂
Molecular Weight:2559.08
Sequence:CLLFVY CGRKKRRQRRRPPQ*(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
Purity:≥95%
Appearance:White, lyophilized solid
Mass Spectrum:Consistent with structure
Counter Ion:TFA
Solubility:Soluble to 1mg/ml in water
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
