85-5892-10　Shield 1 5mg　CAS No:914805-33-7　466066

特徴

• Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.
• Synonyms:1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-,(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-2-Piperidinecarboxylic Acid
• Molecular Formula:C42H56N2O10
• Molecular Weight:748.9
• Appearance:White to off-white solid
• Purity:≥99%
• Solubility:Chloroform (Slightly), Methanol (Slightly)
• Method for Determining Ientity:Proton NMR Spectroscopic and Mass Spectrometric analysis
• TLC Conditions:SiO2; Dichloromethane:Methanol=9:1; Visualized with UV and KMnO4; Single Spot, Rf=0.75
• Elemental Analysis:Calculated: %C: 67.36, %H: 7.54, %N: 3.74
• Specific Rotation (c=0.2, Methanol):As Reported
• Storage and Stability:Store at 4°C. Hygroscopic; Store under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.