85-5868-91　Rocaglamide (Roc-A) 1mg　464800

特徴

• Rocaglamide is derived from a Chinese medicinal plant Aglaia. Rocaglamide induces apoptosis in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.
• Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
• Synonyms:Rocaglamide A; RocA; NSC 326408; (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
• Molecular Formula:C₂₉H₃₁NO₇
• Molecular Weight:505.56
• Appearance:White to off-white powder
• Purity:≥98%
• Solubility:DMSO: 150mg/ml (sonicate)
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.