85-5845-56　(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole 50mg　CAS No:94944-70-4　463494

特徴

• (R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI) inhibits sphinogosine-1-phosphate (S1P) lyase for treatment of autoimmune disorders. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists
• 2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.
• Synonyms:1-[5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone; [1R-(1R*,2S*,3R*)]-1-[4-(1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl]-ethanone; 2-ATHBI
• Molecular Formula:C₉H₁₄N₂O₅
• Molecular Weight:230.22
• Appearance:Off-white to light brown solid
• Purity:≥96%
• Melting Point:>200ºC (dec.)
• Solubility:Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated)
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.