85-5810-95　Oligomycin D (Rutamycin A) 500ug　CAS No:1404-59-7　461533

特徴

• Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport.1 Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36uM.
• Synonyms:(1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-22-Ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione; Spiro[2,26-dioxabicyclo[23.3.1]nonacosane-27,2'-[2H]pyran], oligomycin A deriv.; A 272; Oligomycin D; RR 32705; Rutamycin A
• Molecular Formula:C44H72O11
• Molecular Weight:777.04
• Appearance:White to off-white powder
• Purity:≥95%
• Solubility:DMF, DMSO, Ethanol, Methanol
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.