85-5676-06　MCC-950 1mg　CAS No:210826-40-7　454224

特徴

• NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer’s disease, and atherosclerosis.1 MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM).2 It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin.2 MCC-950 is active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome.2 It is also active in ex vivo samples from individuals with Muckle-Wells syndrome.
• Synonym:N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide; CP 456,773
• Molecular Formula:C20H24N2O5S
• Molecular Weight:404.48
• Appearance:Crystalline solid
• Purity:≥98%
• Solubility:Soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of MCC950 in ethanol is approximately 0.5 mg/ml and approximately 30 mg/ml in DMSO and DMF.
• Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, MCC950 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. MCC950 has a solubility of approximately 0.5mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.