Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30ug/ml.
Synonyms:1-Hexadecylmercapto-2-methoxymethyl-3-propyl Phosphoric Acid Monocholine Ester; BM 41440; Thio ALP
Molecular Formula:C₂₆H₅₆NO₅PS
Molecular Weight:525.77
Solubility:H2O (10mg/ml)
Method for Determining Identity:Proton NMR
Purity:≥97% (NMR)
Appearance:Semisolid (waxy)
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
