85-5639-18　Idasanutlin (RG7388, ?RO 5503781) 50mg　452193

特徴

• Idasanutlin is a selective MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments. RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30nM).1 By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice.1,2 RG7388 is orally available and prolonged daily administration results in loss of MDM2 and p21 protein, growth inhibition, and apoptosis in SJSA1 xenograft tumors.2 Like other MDM2 inhibitors, RG7388 competitively inhibits multi-drug resistance protein 1 (MRP1) and reverse MRP1-mediated multidrug resistance in cancer cells in a p53-independent manner.3
• Synonyms:4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-benzoic Acid; RG 7388; RO 5503781
• Molecular Formula:C₃₁H₂₉Cl₂F₂N₃O₄
• Molecular Weight:616.48
• Purity:≥99%
• Appearance:White to off-white crystalline solid
• λmax:220, 274, 302nm
• Solubility:DMSO: >50mg/ml
• Storage and Stability:May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with dH2O or solvent. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap