85-5638-83　［受注停止］Icatibant Acetate (HOE 140) 5mg　CAS No:138614-30-9　452174

特徴

• Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE). Icatibant is a synthetic peptide antagonist of the bradykinin B2 receptor with IC50 and Ki values of 1.07 and 0.798nM, respectively, in guinea pig ileal cell membranes.1 It inhibits bradykinin-induced contractions in isolated guinea pig ileum and pulmonary arteries as well as in rat uterus (IC50s = 11, 5.4, and 4.9nM, respectively). In vivo, icatibant inhibits bronchoconstriction induced by bradykinin in a guinea pig model (ID50s = 13.4 and 31.8pmol/kg, i.v., for pulmonary resistance and dynamic lung compliance, respectively).1 Icatibant (30ug, i.v.) also reduces vascular permeability in the footpad and intestine in a mouse model of hereditary angioedema.2 Formulations containing icatibant have been used for the treatment of hereditary angioedema.
• Synonyms:D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-L-arginine Acetate Salt; D-Arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3aβ,7aβ)-octahydro-1H-indole-2-carbonyl-L-arginine Acetate Salt; Firazyr; HOE 140
• Molecular Formula:C₅₉H₈₉N₁₉O₁₃S x(C ₂H₄O₂)
• Molecular Weight:1304.52
• Appearance:White solid
• Purity:≥98%
• Melting Point:208-218°C
• Solubility:DMSO (Slightly), Water (Slightly)
• Storage and Stability:May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with solvent. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Store under inert atmosphere
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.