Herbicidin A is an adenine nucleoside antibiotic originally isolated from S. saganonensis that exhibits herbicidal activity, particularly against dicotyledonous plants.1,2 It prevents rice seed germination (MIC = 6.25 ug/ml) and completely protects young rice plants from X. oryzae-induced leaf blight when applied at 100 ppm.1 In HEK293 cells, herbicidin A inhibits TNF-α-induced NF-κB activity and induces cytotoxicity (IC50s = 1.8 and 2.7 uM, respectively).3
Solubility and Usage:Herbicidin A is supplied as a solid. A stock solution may be made by dissolving the herbicidin A in the solvent of choice. Herbicidin A is soluble in organic solvents such as ethanol, methanol, DMSO, and dimethyl formamide, which should be purged with an inert gas.
Purity:≥95%
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.