85-5626-95　Guaiol 50mg　CAS No:489-86-1　451503

特徴

• (−)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.1,2,3 It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively).1 It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (−)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.2 (−)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively).3
• Synonyms:1,2,3,4,5β,6,7,8-Octahydro-α,α,3α,8α-tetramethyl-5-azulenemethanolGuai-1(5)-en-11-ol; Guaiol; (3S,5R,8S)-1,2,3,4,5,6,7,8-Octahydro-α,α,3,8-tetramethyl-5-azulenemethanol; (-)-Guaiol; 3,8-Dimethyl-5-α-hydroxyisopropyl-Δ9-octahydroazulene; Champaca Camphor; Champacol; Guaiac Alcohol; NSC 19941
• Molecular Formula:C₁₅H₂₆O
• Molecular Weight:222.37
• Appearance:White to off-white solid
• Purity:≥95%
• Melting Point:89-91°C
• Solubility:Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.