85-5554-83　［取扱停止］Doravirine (MK-1439) 5mg　CAS No:1338225-97-0　447665

特徴

• Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11nM).1 It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.
• Synonyms:3-Chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile; MK-1439
• Molecular Formula:C17H11ClF3N5O3
• Molecular Weight:425.75
• Purity:≥98%
• Appearance:White to off-white solid
• Melting Point:>278°C (dec.)
• Solubility:DMSO (Slightly), Methanol (Slightly)
• Storage and Stability:May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.