85-5554-53　Dolutegravir Sodium Salt 2mg　CAS No:1051375-19-9,Free Amine: 1051375-16-6　447645

特徴

• Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
• Synonyms:Dolutegravir sodium; GSK 1349572A; N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Sodium Salt
• Molecular Formula:C₂₀H₁₈F₂N₃NaO₅
• Molecular Weight:441.36
• Appearance:White to green solid
• Purity:≥98%
• NMR:Conforms to structure
• Elemental Analysis:%C: 53.80, %H: 3.86, %N: 9.33
• MS:Conforms to structure
• TLC Conditions:C18; Methanol: Water = 9: 1; Visualized with UV and AMCS; Rf = 0.60
• Specific Rotation:30.6° (c = 0.1, DMSO
• Melting Point:>300ºC
• Solubility:DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• Storage and Stability:Store at -20°C. Hygroscopic. Under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.