85-5508-97　CRANAD 28 5mg　CAS No:1623747-97-6　445116

特徴

• CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578nm, respectively.1 It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
• Synonyms:(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
• Molecular Formula:C27H23BF2N4O2
• Molecular Weight:484.3
• Appearance:As reported
• Purity:≥98% (HPLC)
• Emission:578nm
• Excitation:498nm
• λmax:245, 479nm
• Solubility:DMF: 2mg/mlDMSO: 2mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5mg/ml
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.