85-5490-33　cDPCP 10mg　CAS No:106343-54-8　444080

特徴

• cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.
• Synonyms:cis-Diammine(pyridine)chloroplatinum(II) chloride, Pyriplatin, cis-[Pt(NH3)2(py)Cl]+ chloride; (SP-4-2)-Diamminechloro(pyridine)-platinum(1+) Chloride
• Molecular Formula:C₅H₁₁ClN₃Pt•Cl
• Molecular Weight:343.70
• Appearance:Yellow solid
• Purity:≥95%
• Elemental Analysis:(Theoretical) %C: 15.84, %H: 2.92, %N: 11.08(Actual) %C: 16.02, %H: 2.97, %N: 11.55
• NMR:Conforms to Structure
• MS:Conforms to Structure
• TLC Conditions:SiO2; Dichloromethane : Methanol = 8 : 2; Visualized with UV and KMnO4; Single Spot, Rf = 0.30.Elemental Analysis:
• Melting Point:>240°C (dec.)
• Chloride:~11% by Ion Chromatography
• Solubility:DMSO (Slightly), Water (Slightly)
• Storage and Stability:Store at 4°C. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.