85-5471-34　Bithionol 25g　CAS No:97-18-7　443018

特徴

• Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.1,2,3 Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.4 By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.4 Bithionol also inhibits NF-κB activation by blocking phosphorylation of IκBα (IC50 = 15.8uM in a reporter gene assay).5
• Synonyms:2,2'-thiobis[4,6-dichloro-phenol]; Bis(3,5-dichloro-2-hydroxyphenyl) Sulfide
• Molecular Formula:C₁₂H₆Cl₄O₂S
• Molecular Weight:356.05
• Appearance:356.05
• Purity≥97% (GC)
• Melting Point:184-188°C
• Solubility:Methanol
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.