85-5465-21　BI-847325 25mg　CAS No:1207293-36-4　442678

特徴

• BI-847325 is a novel ATP-competitive MEK and Aurora kinase inhibitor. It can inhibit the growth of BRAF resistant melanoma cells through suppression of Mcl-1 and MEK expression in human melanoma cell lines and mouse xenograft model. The efficacy of BI-847325 was studied in patients with refractory solid tumors.
• Synonyms:3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide; (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide; BI 847325
• Molecular Formula:C₂₉H₂₈N₄O₂
• Molecular Weight:464.56
• Appearance:Crystalline solid
• Purity:≥99%
• Solubility:DMF: 16mg/mlDMF:PBS(pH 7.2)(1:6): 0.14mg/mlDMSO: 5mg/mlEthanol: 0.3mg/ml
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.